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THX6

CAT: 0804-HY-172199-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-172199-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
THX6 is the activator for human mitochondrial protease ClpP with an EC50 of 1.18 μM. THX6 exhibits cytotoxicity in ONC201-resistant cell SU-DIPG-VI with IC50 of 0.13 μM. THX6 inhibits the expression of mitochondrial-related proteins (such as parkin, TFAM, NRF1, SDHA), leads to impaired mitochondrial function. THX6 affects the lipid metabolism in cell membran, and exhibits antitumor potential[1].
CAS Number
3076954-42-9
UNSPSC
12352005
Target
ClpP; Mitochondrial Metabolism
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
N#CC1=CC=CC(CN2CCC3=C(C(N(C(N3)=O)CC4=CC=C(C(Cl)=C4)Cl)=O)C2)=C1
Molecular Formula
C22H18Cl2N4O2
Molecular Weight
441.31
References & Citations
[1]Miciaccia M, et al., ONC201-Derived Tetrahydropyridopyrimidindiones as Powerful ClpP Protease Activators to Tackle Diffuse Midline Glioma. J Med Chem. 2025 Mar 13;68 (5) :5190-5210.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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