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THX6

CAT: 0931-T205692-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205692-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Mitochondrial Metabolism, Protease
Related Pathways
Metabolism, Proteases/Proteasome
Bioactivity
THX6 is an activator of human mitochondrial protease ClpP, with an EC50 of 1.18 μM. It displays cytotoxicity in ONC201-resistant SU-DIPG-VI cells, with an IC50 of 0.13 μM. THX6 inhibits the expression of mitochondria-related proteins (such as parkin, TFAM, NRF1, SDHA), leading to impaired mitochondrial function. Additionally, THX6 affects cell membrane lipid metabolism and exhibits antitumor potential.
Molecular Formula
C22H18Cl2N4O2
Molecular Weight
441.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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CatalogName
HY-172199-01THX6

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