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H122

CAT: 0804-HY-172113-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-172113-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
H122 is a PROTAC degrader for TEAD that degrades TEAD1 with a DC50 of 3 nM, and exhibits good affinity to TEAD2, TEAD3, and TEAD4 with Ki of 2.0, 3.6 and 1.6 nM. H122 downregulates the expression of Myc. H122 inhibits the cell growth of MSTO-211H and NCI-H226 with IC50 of 21.3 nM and 0.6 nM, and exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein ; Black: linker (HY-W573128) ; Blue: ligand for E3 ligase Cereblon (HY-W087383) )
UNSPSC
12352005
Target
C-Myc; PROTACs; YAP
Related Pathways
Apoptosis; PROTAC; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.33
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COCCOC1=C([C@@]([C@@]2=C(C=CC3=C2C[C@@](C4=CC=CC=C4)(O3)CNCCC5CCN(CC5)C6=CC=C(C7=C6)C(N(C7=O)C8C(NC(CC8)=O)=O)=O)Cl)=C(C=C1)C(N)=O)F
Molecular Formula
C45H45ClFN5O8
Molecular Weight
838.32
References & Citations
[1]Lu Y, et al., Selective Degradation of TEADs by a PROTAC Molecule Exhibited Robust Anticancer Efficacy In Vitro and In Vivo. J Med Chem. 2025 Jan 13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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