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H122

CAT: 0013-GTR19249720-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249720-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
H122 is a potent TEAD-targeting PROTAC degrader with low nanomolar activity against TEAD1-4. It downregulates Myc expression, inhibits mesothelioma cell growth in vitro, and demonstrates antitumor efficacy in mouse models, supporting research in Hippo pathway and cancer therapeutics.
Field of Research
Cell Biology, Pharmacology & Drug Discovery, Stem Cell & Developmental Biology
Smiles
COCCOC1=C (C (=C (C=C1) C (=O) N) C2=C (C=CC3=C2C[C@@] (O3) (CNCCC4CCN (CC4) C5=CC6=C (C=C5) C (=O) N (C6=O) C7CCC (=O) NC7=O) C8=CC=CC=C8) Cl) F
Molecular Formula
C45H45ClFN5O8
Molecular Weight
838.319
Storage Conditions
-20°C
Notes
For research use only.

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