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LY3526318

CAT: 0804-HY-171846-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-171846-01Size:5 mg
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Description
LY3526318 is an orally active, selective TRPA1 antagonist (IC50=5-6μM) . LY3526318 blocks TRPA1 channels, inhibits pain signal transduction mediated by the channel, and exerts analgesic activity. LY3526318 is mainly used in the research of chronic pain-related fields, such as diabetic peripheral neuropathy, chronic low back pain, and pain caused by osteoarthritis[1][2].
CAS Number
1889218-34-1
UNSPSC
12352005
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Inflammation/Immunology; Neurological Disease
Purity
99.92
Solubility
DMSO : 80 mg/mL (ultrasonic)
Smiles
FC(F)(F)C1=NC=C(C=N1)C2=NC(NC([C@@H](N3C4=C(N=C3)N(C(N(C4=O)CC5=NC(C)=NO5)=O)C)C)=O)=CC=C2
Molecular Formula
C23H19F3N10O4
Molecular Weight
556.46
References & Citations
[1]Bamps D, et al. TRPA1 Antagonist LY3526318 Inhibits the Cinnamaldehyde-Evoked Dermal Blood Flow Increase: Translational Proof of Pharmacology. Clin Pharmacol Ther. 2023 Nov;114 (5) :1093-1103.|[2]Broad LM, et al. Preclinical and clinical evaluation of a novel TRPA1 antagonist LY3526318. Pain. 2025 Apr 18.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPA1

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