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LY3526318

CAT: 0931-T210559-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210559-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1889218-34-1
Target
TRP/TRPV Channel
Related Pathways
Membrane transporter/Ion channel
Bioactivity
LY3526318 is an orally active, selective TRPA1 antagonist with an IC50 of 5-6 μM. It blocks the TRPA1 channel, inhibiting pain signal transduction mediated by this channel and demonstrating analgesic activity. LY3526318 is primarily utilized in research related to chronic pain, such as diabetic peripheral neuropathic pain, chronic lower back pain, and osteoarthritis-induced pain.
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[C@@H](C(NC=1N=C(C=CC1)C=2C=NC(C(F)(F)F)=NC2)=O)(C)N3C4=C(N(C)C(=O)N(CC5=NC(C)=NO5)C4=O)N=C3
Molecular Formula
C23H19F3N10O4
Molecular Weight
556.46
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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