Products for Research Use Only
RegisterLogin

SK2187

CAT: 0804-HY-171768-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-171768-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SK2187 is a selective AURKA PROTAC degrader with a DC50 of about 10 nM. SK2187 exhibits growth inhibition against NGP cells with an IC50 of 101.5 nM. SK2187 can be used for the study of MYCN-amplified neuroblastoma (Pink: AURKA ligand: MK-5108 ; Blue: E3 ligand (HY-103597) ; Black: Linker: Amino-PEG3-alcohol (HY-W015088) ).
CAS Number
3038446-91-9
Product Name Alternative
JB301
UNSPSC
12352005
Target
Aurora Kinase; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Purity
95.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCC(NCCOCCOCCOCCNC([C@@]4(CC[C@H](CC4)OC5=C(C(Cl)=CC=C5)F)CC6=CC=CC(NC7=NC=CS7)=N6)=O)=O)=C3C1=O
Molecular Formula
C45H49ClFN7O11S
Molecular Weight
950.43
References & Citations
[1]Muhammad Rishf, et al. Targeted AURKA degradation: Towards new therapeutic agents for neuroblastoma. Eur J Med Chem. 2023 Feb 5:247:115033.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

4-(3-chloro-2-fluorophenoxy)-N-[2-[2-[2-[2-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]ethoxy]ethoxy]ethoxy]ethyl]-1-[[6-(1,3-thiazol-2-ylamino)-2-pyridinyl]methyl]cyclohexane-1-carboxamide
CAS Number3038446-91-9
PubChem CID172451495
IUPAC Name4-(3-chloro-2-fluorophenoxy)-N-[2-[2-[2-[2-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]ethoxy]ethoxy]ethoxy]ethyl]-1-[[6-(1,3-thiazol-2-ylamino)-2-pyridinyl]methyl]cyclohexane-1-carboxamide
Molecular FormulaC45H49ClFN7O11S
Molecular Weight950.4
XLogP3.9
Topological Polar Surface Area254
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count16
Rotatable Bond Count23
Heavy Atom Count66
Formal Charge0
Complexity1670
SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)NCCOCCOCCOCCNC(=O)C4(CCC(CC4)OC5=C(C(=CC=C5)Cl)F)CC6=NC(=CC=C6)NC7=NC=CS7
InChI
InChI=1S/C45H49ClFN7O11S/c46-31-6-3-8-34(39(31)47)65-29-12-14-45(15-13-29,26-28-4-1-9-35(51-28)52-44-50-18-25-66-44)43(60)49-17-20-62-22-24-63-23-21-61-19-16-48-37(56)27-64-33-7-2-5-30-38(33)42(59)54(41(30)58)32-10-11-36(55)53-40(32)57/h1-9,18,25,29,32H,10-17,19-24,26-27H2,(H,48,56)(H,49,60)(H,50,51,52)(H,53,55,57)
InChIKey
ROINLDWZNWCWJK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-(3-chloro-2-fluorophenoxy)-N-[2-[2-[2-[2-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]ethoxy]ethoxy]ethoxy]ethyl]-1-[[6-(1,3-thiazol-2-ylamino)-2-pyridinyl]methyl]cyclohexane-1-carboxamide
CAS: 3038446-91-9
CID: 172451495
Formula: C45H49ClFN7O11S
MW: 950.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight950.4
XLogP33.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count16
Rotatable Bond Count23
Exact Mass949.2883324
Monoisotopic Mass949.2883324
Topological Polar Surface Area254 Ų
Heavy Atom Count66
Formal Charge0
Complexity1670
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-171767-01SK2188

Alternative Products

CatalogName
GTR19263815-01SK2187

Popular Products