KMS99220

CAT: 0804-HY-171705-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-171705-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

KMS99220 is an orally active Nrf2 inhibitory protein Keap-1 activator. KMS99220 promotes Nrf2 nuclear translocation, up-regulates the gene expression of antioxidant enzymes (such as heme oxygenase-1, etc.) and proteasome subunits, alleviates oxidative stress and protein aggregation damage. KMS99220 can be used in the research of Parkinson’s disease (PD) [1].

CAS Number

1478585-60-2

UNSPSC

12352005

Target

Keap1-Nrf2

Related Pathways

NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Purity

99.48

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=C(C=C1)OCCCN2CCOCC2)/C=C/C3=C(C=CC=C3)C(F)(F)F.Cl

Molecular Formula

C23H25ClF3NO3

Molecular Weight

455.90

References & Citations

[1]Lee JA, et al. Activation of the Nrf2 signaling pathway and neuroprotection of nigral dopaminergic neurons by a novel synthetic compound KMS99220. Neurochem Int. 2018 Jan;112:96-107.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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