PRDX1-IN-3

• Description :

  PRDX1-IN-3 (compound 19-048) is a PRDX1 covalent inhibitor with anti-colorectal cancer activity. PRDX1-IN-3 can effectively inhibit the proliferation of colorectal cancer cells, and its antitumor effect on nude mice with colorectal cancer carrying PRDX1 gene knockout is significantly reduced. PRDX1-IN-3 also upregulates the downstream genes of the p53 signaling pathway to exert an anticancer effect[1].

• UNSPSC :

  12352211

• Target :

  MDM-2/p53; Reactive Oxygen Species (ROS)

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Purity :

  99.52

• Solubility :

  DMSO : 12.5 mg/mL (ultrasonic)

• Smiles :

  C[C@@]12[C@]([C@@]3([H])[C@@](CC1)(CC[C@](C)(C3)NC(N[C@@H](C)C(OC)=O)=O)C)(CC[C@@]4(C2=CC=C5C4=CC(C(O)=C5C)=O)C)C

• Molecular Formula :

  C33H46N2O5

• Molecular Weight :

  550.73

• References & Citations :

  [1]Xu H, et al. Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1. Signal Transduct Target Ther. 2023 Feb 3;8 (1) :51.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2566976-46-1]