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AF615

CAT: 0804-HY-171180-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-171180-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AF615 is a small molecule inhibitor targeting the CDT1/Geminin protein complex (IC50 = 0.313 μM) . AF615 selectively induces DNA damage, inhibits DNA synthesis, causes cell cycle arrest, and decreases the survival rate in cancer cell lines. AF615 displayed a Ki = 0.37 μM in case of Geminin-tCDT1 interaction and a Ki = 0.75 μM in case of Geminin-miniCDT1 interaction[1].
CAS Number
122510-61-6
UNSPSC
12352005
Target
DNA/RNA Synthesis
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Purity
99.43
Solubility
DMSO : 26.74 mg/mL (ultrasonic)
Smiles
O=C(C1=NC=CN=C1)NNC(N2CCOCC2)=S
Molecular Formula
C10H13N5O2S
Molecular Weight
267.31
References & Citations
[1]Nikolaos Karantzelis, et al. Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells. Front Pharmacol. 2022 Apr 25;13:860682.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19231892-01AF615

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