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CQ1373

CAT: 0804-HY-170926Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170926Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CQ1373 is a potent RET inhibitor, demonstrating cellular potency with IC50 values of 13.0, 25.7 and 28.4 nM against BaF3 cells expressing CCDC6-RET, CCDC6-RET-G810C and CCDC6-RET-G810R, respectively. CQ1373 exhibits good selectivity toward wild-type RET and solvent front mutants G810C/R with IC50 values of 4.2, 7.1 and 32.4 nM, respectively. CQ1373 inhibits RET phosphorylation and downstream signaling through SHC. CQ1373 induces Apoptosis and cell cycle arrest in BaF3 cells. CQ1373 exhibits anti-tumor efficacy and can be used for cancer research[1].
UNSPSC
12352005
Target
Apoptosis; RET
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CC(C)(C(F)(F)F)C1=CC(NC(NC2=C(Cl)C=C(/C=C/C3=C(C4=CN=CC(OC)=C4)C=NN3)C=C2)=O)=NO1
Molecular Formula
C25H22ClF3N6O3
Molecular Weight
546.93
References & Citations
[1]Xu M, et al. Design, synthesis and evaluation of (E) -1- (4- (2- (1H-pyrazol-5-yl) vinyl) phenyl) derivatives as next generation selective RET inhibitors overcoming RET solvent front mutations (G810C/R) . Eur J Med Chem. 2025 Mar 15;286:117294.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T205249-01CQ1373

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