Pellotine

• Description :

  Pellotine is an alkaloid that can be isolated from Lophophora. Pellotine is the inverse agonist for 5-HT7 receptor with an EC50 of 291 nM. Pellotine exhibits good affinity to 5-HT1DR and 5-HT6R with Ki of 117 nM and 170 nM. Pellotine reduces intracellular cAMP levels, thereby reducing neuronal excitability and neurotransmitter release[1].

• CAS Number :

  [19622-05-0]

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Smiles :

  COC1=C(OC)C(O)=C(C(C)N(C)CC2)C2=C1

• Molecular Formula :

  C13H19NO3

• Molecular Weight :

  237.29

• References & Citations :

  [1]Chan CB, et al., Synthesis, Pharmacological Characterization, and Binding Mode Analysis of 8-Hydroxy-Tetrahydroisoquinolines as 5-HT7 Receptor Inverse Agonists. ACS Chem Neurosci. 2025 Feb 5;16 (3) :439-451.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT7 Receptor; mLAG-3; MUC2; MUC3