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P162-0948

CAT: 0804-HY-170813Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-170813Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. P162-0948 reduces cell migration and protein expression of EMT-related proteins in A549 human alveolar epithelial cell lines. P162-0948 reduces phosphorylation of Smad, which suggests disruption of the TGF-β/Smad signaling pathway. P162-0948 is promising for research of pulmonary fibrosis[1].
CAS Number
[1358201-44-1]
UNSPSC
12352005
Target
CDK; TGF-beta/Smad
Related Pathways
Cell Cycle/DNA Damage; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Infection
Smiles
FC1=CC=C(CNC(CC2=NN=C(C3=CC=C4C(C=CC=N4)=C3)O2)=O)C=C1
Molecular Formula
C20H15FN4O2
Molecular Weight
362.36
References & Citations
[1]Lin TE, et al. Identification of a Potent CDK8 Inhibitor Using Structure-Based Virtual Screening. J Chem Inf Model. 2025 Jan 13;65 (1) :378-389.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK8

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Alternative Products

CatalogName
T205592-01P162-0948
362922EEA1 (Early Endosome Antigen 1, ZFYVE2, Endosome-associated protein p162, Zinc finger FYVE domain-containing protein 2)
222309-01EEA1 (Early endosome Antigen 1, Endosome-Associated Protein p162, Zinc Finger FYVE Domain-Containing Protein 2, ZFYVE2) discontinued
126164-PEEEA1 (ZFYVE2, Early Endosome Antigen 1, Endosome-associated Protein p162, Zinc Finger FYVE Domain-containing Protein 2, MSTP105, MST105) (PE) discontinued
126164EEA1 (ZFYVE2, Early Endosome Antigen 1, Endosome-associated Protein p162, Zinc Finger FYVE Domain-containing Protein 2, MSTP105, MST105) discontinued
E2211-02EEA1 (Early Endosomal Antigen 1, Early Endosome Associated Protein, Endosome Associated Protein p162, ZFYVE2, Zinc Finger FYVE Domain Containing Protein 2) discontinued
E2211-01EEEA1 (Early Endosomal Antigen 1, Early Endosome Associated Protein, Endosome Associated Protein p162, ZFYVE2, Zinc Finger FYVE Domain Containing Protein 2)
126164-BiotinEEA1 (ZFYVE2, Early Endosome Antigen 1, Endosome-associated Protein p162, Zinc Finger FYVE Domain-containing Protein 2, MSTP105, MST105) (Biotin) discontinued
126164-HRPEEA1 (ZFYVE2, Early Endosome Antigen 1, Endosome-associated Protein p162, Zinc Finger FYVE Domain-containing Protein 2, MSTP105, MST105) (HRP) discontinued
126164-APEEA1 (ZFYVE2, Early Endosome Antigen 1, Endosome-associated Protein p162, Zinc Finger FYVE Domain-containing Protein 2, MSTP105, MST105) (AP) discontinued

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