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PDE7A-IN-1

CAT: 0804-HY-170788Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170788Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDE7A-IN-1 (Compound 26) is an orally active PDE7A inhibitor with an IC50 value of 3.7 nM. PDE7A-IN-1 significantly improves bone mineral density by inhibiting the sclerostin (sclerostin) and is suitable for the study of osteoporosis and related bone metabolic diseases[1].
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=C1N(CC)C(N[C@H]2CN(C(C3=NC=C(C4=CC=CC=C4)C=C3)=O)CC2)=NC(C5CC5)=C1Cl
Molecular Formula
C25H26ClN5O2
Molecular Weight
463.96
References & Citations
[1]Kondo K, et al. Discovery of a Phosphodiesterase 7A Inhibitor of High Isozyme Selectivity Exhibiting In Vivo Anti-Osteoporotic Effects. ACS Med Chem Lett. 2024 Dec 27;16 (1) :167-173.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE7

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