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FW-1

CAT: 0804-HY-170558Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170558Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FW-1 is a type I inhibitor for FLT3 with IC50 of ca. 1 μM. FW-1 exhibits cytotoxicity in FLT3 mutated AML cell. FW-1 arrests the cell cycle at G0/G1 phase, and induces apoptosis in cell MV4-11 and MOLM-13[1].
UNSPSC
12352005
Target
Apoptosis; FLT3
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
NC1=NOC2=NC(NC3=CC=C(CN4CCN(C)CC4)C=C3)=CC(NC5=CC=CC=C5)=C21
Molecular Formula
C24H27N7O
Molecular Weight
429.52
References & Citations
[1]Yang J, et al., Design, Synthesis, and Biological Activities Evaluation of Type I FLT3 Inhibitors for the Treatment of Acute Myeloid Leukemia. Drug Dev Res. 2024 Dec;85 (8) :e70022.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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