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ADS1017

CAT: 0804-HY-170444Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170444Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ADS1017 is the antagonist for histamine receptor and muscarinic receptor, that exhibits good affinities to hH3R, hH4R, hM2R and hM4R with pKi of 6.8, 5.5, 7.4 and 7.2. ADS1017 exhibits analgesic and anti-allodynic efficacy in mice Capsaicin -or Oxaliplatin (HY-17371) -induced pain models[1].
UNSPSC
12352005
Target
Histamine Receptor; mAChR
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
NC(N(CCCCN1CCN(CCCCCCCOC2=CC=CC=C2)CC1)CC3=CC=CC=C3)=N
Molecular Formula
C29H45N5O
Molecular Weight
479.70
References & Citations
[1]Karcz T, et al., Guanidine Derivative ADS1017, a Potent Histamine H3 Receptor Antagonist with Promising Analgesic Activity and Satisfactory Safety Profile. ACS Chem Neurosci. 2024 Dec 18;15 (24) :4441-4457.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T204233-01ADS1017

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