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DefNEtTrp

CAT: 0804-HY-170433Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170433Size:1 Each
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Description
DefNEtTrp is a Fe dual chelator ligand, consisting of the Def and Trp moieties. DefNEtTrp exhibits potent and broad-spectrum antiproliferative and cell death behavior in cancer cell lines. DefNEtTrp induces both apoptosis and ferroptosis and has cytotoxicity with an IC50 value of 0.77 μM[1].
UNSPSC
12352005
Target
Apoptosis; Ferroptosis
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
OC1=C(C2=NN(C3=CC=C(C(NCCNC(N/N=C/C4=C(N)C=CC=N4)=S)=O)C=C3)C(C5=CC=CC=C5O)=N2)C=CC=C1
Molecular Formula
C30H27N9O3S
Molecular Weight
593.66
References & Citations
[1]Rodríguez I, et al. DefNEtTrp: An Iron Dual Chelator Approach for Anticancer Application. JACS Au. 2024 Dec 4;4 (12) :4799-4808.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T204913-01DefNEtTrp

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