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BNN27

CAT: 0804-HY-170409Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170409Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BNN27 is the agonist for TrkA receptor and p75NTR receptor, that exhibits neurotrophic and anti-apoptotic effects. BNN27 increases the levels of glutamate, GABA, and glutamine in the rat hippocampus and prefrontal cortex, improves glutamate turnover. BNN27 exhibits neuroprotective efficacy in mouse amyotrophic lateral sclerosis (ALS) model, exhibits anti-inflammatory efficacy in experimental autoimmune encephalomyelitis (EAE) model, exhibits retinal protective efficacy in rat diabete models. BNN27 is blood-brain barrier penetrable[1].
CAS Number
1195795-81-3
UNSPSC
12352005
Target
Apoptosis; Trk Receptor
Related Pathways
Apoptosis; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
C[C@@]12[C@]3(CC[C@@]1([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H](CC5)O)=CC4)C)([H])CC2)[C@H](O3)CO
Molecular Formula
C21H32O3
Molecular Weight
332.48
References & Citations
[1]Kokras N, et al., Psychoactive properties of BNN27, a novel neurosteroid derivate, in male and female rats. Psychopharmacology (Berl) . 2020 Aug;237 (8) :2435-2449.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19249681-01BNN27

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