BNN27

CAT: 0931-T204974-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T204974-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1195795-81-3

Target

Apoptosis, Trk receptor

Related Pathways

Tyrosine Kinase/Adaptors, Apoptosis

Bioactivity

BNN27 is an agonist of the TrkA receptor (TrkAreceptor) and the p75NTR receptor (p75NTR receptor), exhibiting neurotrophic and anti-apoptotic properties. It enhances levels of glutamate, GABA, and glutamine in the hippocampus and prefrontal cortex of rats, improving glutamate turnover. In a mouse model of amyotrophic lateral sclerosis (ALS), BNN27 demonstrates neuroprotective effects, shows anti-inflammatory properties in an experimental autoimmune encephalomyelitis (EAE) model, and exhibits retinal protection in a rat diabetes model. BNN27 also possesses blood-brain barrier permeability.

Smiles

C[C@@]12[C@@]3([C@@H](CO)O3)CC[C@]1([C@]4([C@](CC2)([C@]5(C)C(=CC4)C[C@@H](O)CC5)[H])[H])[H]

Molecular Formula

C21H32O3

Molecular Weight

332.477

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Alternative Products

Catalog	Name
GTR19249681-01	BNN27

BNN27

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