Argiotoxin 636

• Description:

  Argiotoxin 636 is a toxin and the non-specific, non-competitive, and potent ionotropic glutamate receptor (iGluR) antagonist. Argiotoxin 636 blocks excitatory synaptic transmission in neurons and has paralysis and muscle relaxation effects. Argiotoxin 636 can be used in the study of nervous system diseases[1][2].

• UNSPSC:

  12352211

• Target:

  IGluR

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Smiles:

  N=C (N) NCCC[C@H] (N) C (NCCCNCCCNCCCCCNC ([C@H] (CC (N) =O) NC (CC1=C (C=C (C=C1) O) O) =O) =O) =O

• Molecular Formula:

  C29H52N10O6

• Molecular Weight:

  636.79

• References & Citations:

  [1]Adams ME, et al. Structures and biological activities of three synaptic antagonists from orb weaver spider venom. Biochem Biophys Res Commun. 1987 Oct 29;148 (2) :678-83.|[2]Ashe JH, et al. Argiotoxin-636 blocks excitatory synaptic transmission in rat hippocampal CA1 pyramidal neurons. Brain Res. 1989 Feb 20;480 (1-2) :234-41.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  105029-41-2