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Lipid N2-3L

CAT: 0804-HY-169478Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169478Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lipid N2-3L is an ionizable cationic lipid (pKa = 8.99) that can be used to generate supramolecular lipid nanoparticles (SMLNPs) for mRNA delivery. Lipid nanoparticles formed by encapsulating a luciferase reporter gene with Lipid N2-3L were detected to accumulate in the lymph nodes of mice, indicating that they can effectively enter the mouse immune system. Lipid nanoparticles formed by encapsulating ovalbumin mRNA and the TLR7/8 agonist Resiquimod with Lipid N2-3L were able to reduce tumor volume and increase survival in the MC-38-OVA mouse colon cancer model. Lipid N2-3L can be used in the research of drug delivery for cancer-related therapies[1].
CAS Number
2924606-55-1
UNSPSC
12352211
Target
Liposome
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
OCCN(CCO)CCCNC(OCCN(CCOC(CCCCCCC/C=C\CCCCCCCC)=O)CCOC(C(CCCCCC)CCCCCCCC)=O)=O
Molecular Formula
C48H93N3O8
Molecular Weight
840.27
References & Citations
[1]Qi S, et al. Supramolecular Lipid Nanoparticles Based on Host-Guest Recognition: A New Generation Delivery System of mRNA Vaccines For Cancer Immunotherapy. Adv Mater. 2024 Jun;36 (23) :e2311574.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported

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