Lipid N2-3L

CAT: 0931-T201886-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T201886-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2924606-55-1

Bioactivity

Lipid N2-3L is an ionizable cationic lipid with a pKa of 8.99, utilized in the formation of supramolecular lipid nanoparticles (SMLNPs) for enclosing mRNA in both in vitro and in vivo applications. Lipid N2-3L-containing SMLNPs accumulate at the injection site and draining lymph nodes in mice, featuring a luciferase reporter gene. Additionally, SMLNPs made with Lipid N2-3L that encapsulate ovalbumin mRNA and the Toll-like receptor 7/8 (TLR7/8) agonist R-848 serve as adjuvants. These enhance dendritic cell maturation and antigen presentation, reducing tumor volume and increasing survival rates in MC-38-OVA colon cancer mouse models.

Smiles

C(C(OCCN(CCOC(NCCCN(CCO)CCO)=O)CCOC(CCCCCCC/C=C\CCCCCCCC)=O)=O)(CCCCCCCC)CCCCCC

Molecular Formula

C48H93N3O8

Molecular Weight

840.27

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-169478	Lipid N2-3L
Y01201-01	FLT-3L
P51317	RBD#3L
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GTR19259803-01	N2, N2-Dimethylmelamine
HY-113137-01	N2, N2-Dimethylguanosine
Z02926-10	Flt-3L, Human
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Lipid N2-3L

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