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GJG057

CAT: 0804-HY-168498-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-168498-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GJG057 is a selective, orally active inhibitor for leukotriene C4 synthase (LTC4S) with an IC50 of 44 nM. GJG057 exhibits anti-inflammatory activity in mouse skin inflammation model and mouse asthma model[1].
CAS Number
2761767-18-2
UNSPSC
12352005
Target
Glutathione S-transferase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Purity
98.82
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1CCCC2(N1C3=CC=C(C(F)=C3)F)CCN(C4=NC=NC(OCC(F)(F)F)=C4)CC2
Molecular Formula
C21H21F5N4O2
Molecular Weight
456.41
References & Citations
[1]Thoma G, et al., Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase. J Med Chem. 2025 Feb 27;68 (4) :4721-4742.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T205247-01GJG057

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