AY 31906

• Description :

  AY 31906 is an orally active pyrimidine sulfonamide diuretic. AY 31906 exhibits potent diuretic and natriuretic activities in rats and dogs, along with relatively potassium-sparing properties. AY 31906 exhibits superior activity to Furosemide (HY-B0135) . AY-31906 also has antihypertensive effects and can be used in the research of cardiovascular diseases[1][2].

• UNSPSC :

  12352005

• Target :

  NKCC; Potassium Channel; Sodium Channel

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Smiles :

  CC(C)NC(NS(=O)(C1=CN=C(N)N=C1N[C@H]2[C@@]3([H])C[C@@](CC3)([H])C2)=O)=O

• Molecular Formula :

  C15H24N6O3S

• Molecular Weight :

  368.45

• References & Citations :

  [1]Ackerman DM, et al. AY-31,906, a novel high ceiling diuretic: characterization of its relative potassium-sparing actions in rats and dogs. J Pharmacol Exp Ther. 1989 Dec;251 (3) :1113-9.|[2]Lang H J, et al. Discovery and development of diuretic agents. Diuretics, 1995: 141-172.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [124788-46-1]