AY 9944

CAT: 0804-HY-107420-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107420-01Size:5 mg
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Description
AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol[1][2][3].
CAS Number
[366-93-8]
UNSPSC
12352005
Hazard Statement
H301
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ay-9944.html
Purity
99.67
Solubility
DMSO : 5 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)
Smiles
ClC(C=CC=C1)=C1CNC[C@H](CC2)CC[C@@H]2CNCC3=C(C=CC=C3)Cl.[H]Cl.[H]Cl
Molecular Formula
C22H30Cl4N2
Molecular Weight
464.30
Precautions
H301
References & Citations
[1]Moebius FF, et al. Molecular cloning and expression of the human delta7-sterol reductase. Proc Natl Acad Sci U S A. 1998 Feb 17;95 (4) :1899-902.|[2]Nemanic MK, et al. In vitro synthesis of vitamin D-3 by cultured human keratinocytes and fibroblasts: action spectrum and effect of AY-9944. Biochim Biophys Acta. 1985 Sep 6;841 (3) :267-77.|[3]Cortez MA, et al. Brain sterols in the AY-9944 rat model of atypical absence seizures. Epilepsia. 2002 Jan;43 (1) :3-8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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