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Tyrphostin A1 (Standard)

CAT: 0804-HY-16668R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16668R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tyrphostin A1 (Standard) is the analytical standard of Tyrphostin A1. This product is intended for research and analytical applications. Tyrphostin A1 (AG9) can inhibit CD40L-stimulated IL-12 production and antigen-induced Th1 cell production in macrophage culture.
CAS Number
2826-26-8
UNSPSC
12352100
Target
Interleukin Related; Reference Standards
Related Pathways
Immunology/Inflammation; Others
Field of Research
Inflammation/Immunology
Smiles
N#C/C(C#N)=C\C1=CC=C(OC)C=C1
Molecular Formula
C11H8N2O
Molecular Weight
184.19
References & Citations
[1]Du C, et al. Inhibition of CD40 signaling pathway by tyrphostin A1 reduces secretion of IL-12 in macrophage, Th1 cell development and experimental allergic encephalomyelitis in SJL/J mice. J Neuroimmunol. 2001 Mar 1;114 (1-2) :69-79.|[2]Ogura T, et al. Activation of background membrane conductance by the tyrosine kinase inhibitor tyrphostin A23 and its inactive analog tyrphostin A1 in guinea pig ventricular myocytes. Jpn J Pharmacol. 2001 Nov;87 (3) :235-9.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Tyrphostin A1

Tyrphostin 1 is a member of methoxybenzenes. It has a role as a geroprotector.

CAS Number2826-26-8
PubChem CID2063
IUPAC Name2-[(4-methoxyphenyl)methylidene]propanedinitrile
Molecular FormulaC11H8N2O
Molecular Weight184.19
XLogP2
Topological Polar Surface Area56.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count14
Formal Charge0
Complexity289
SMILES
COC1=CC=C(C=C1)C=C(C#N)C#N
InChI
InChI=1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3
InChIKey
UOHFCPXBKJPCAD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tyrphostin A1
CAS: 2826-26-8
CID: 2063
Formula: C11H8N2O
MW: 184.19
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight184.19
XLogP32
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass184.063662883
Monoisotopic Mass184.063662883
Topological Polar Surface Area56.8 Ų
Heavy Atom Count14
Formal Charge0
Complexity289
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B1494-50Tyrphostin 9
A4681-50Tyrphostin A1
T7101-01Tyrphostin AG30
T2063-01Tyrphostin 23
T21622-01Tyrphostin A25
468388-01Tyrphostin A9
468386-01Tyrphostin 51
468385-01Tyrphostin 47
T24910-01Tyrphostin A46
T13238-01Tyrphostin AG1433

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