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Telapristone acetate

CAT: 0804-HY-16483Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-16483Size:1 Each
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Description
Telapristone acetate (CDB-4124) is a potent progesterone receptor (PR) modulator. Telapristone acetate inhibits the proliferation of ovarian cancer cells by inducing cell cycle arrest and apoptosis. Telapristone effectively inhibits the occurrence and development of spontaneous and chemically induced mammary tumors in rats. Telapristone acetate can be used for breast and ovarian cancer research[1][2].
CAS Number
198414-31-2
Product Name Alternative
CDB-4124
UNSPSC
12352005
Target
Apoptosis; CDK; PARP; Progesterone Receptor
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer; Endocrinology
Solubility
10 mM in DMSO
Smiles
C[C@@]12[C@](CC[C@]2(OC(C)=O)C(COC)=O)([H])[C@@]3([H])C([C@@H](C4=CC=C(N(C)C)C=C4)C1)=C(CC5)C(CC3)=CC5=O
Molecular Formula
C31H39NO5
Molecular Weight
505.65
References & Citations
[1]Carlos D Gamarra-Luques, et al. Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin-induced cytotoxicity. J Ovarian Res. 2014 Apr 27;7:45.|[2]Wiehle R, et al. CDB-4124, a progesterone receptor modulator, inhibits mammary carcinogenesis by suppressing cell proliferation and inducing apoptosis. Cancer Prev Res (Phila) . 2011 Mar;4 (3) :414-24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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