Products for Research Use Only
RegisterLogin

NS3736

CAT: 0804-HY-164532Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-164532Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
NS3736 is an orally effective chloride channel inhibitor that can be used for the research of osteoporosis. NS3736 targets the CIC-7 channel in osteocytes, blocks osteoclast acidification and resorption in vitro, with IC50=30 μM. In a rat model of ovariectomy-induced osteoporosis, NS3736 can enhance bone strength and bone density[1].
CAS Number
265646-94-4
UNSPSC
12352005
Target
Chloride Channel
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=C(NC1=C(C2=NN=NN2)C=C(Br)C=C1)NC3=CC=C(C(C(F)(F)F)=C3)Cl
Molecular Formula
C15H9BrClF3N6O
Molecular Weight
461.62
References & Citations
[1]Schaller S, et al. The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation. J Bone Miner Res. 2004 Jul;19 (7) :1144-53.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-107603-01NS3763
HY-131879-01NS383

Popular Products