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Cardiomyocyte proliferation promoting agent-1

CAT: 0804-HY-164254-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-164254-01Size:5 mg
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Description
Cardiomyocyte proliferation promoting agent-1 ((E/Z) -GA-002), the E/Z mixture compound, is a cardiomyocyte proliferation promoting agent. GA-002 (single E configuration) is a LATS1 and LATS2 kinase inhibitor with IC50 values of 3.93 nM and 3.87 nM, respectively. GA-002 induces Hippo pathway-regulated gene, inhibits YAP/TAZ phosphorylation, and induces YAP nuclear translocation[1].
CAS Number
2351906-71-1
Product Name Alternative
(E/Z) -GA-002
UNSPSC
12352005
Target
YAP
Related Pathways
Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Cardiovascular Disease
Purity
99.87
Smiles
O=C(C(C)NC1=CC=CC=C1)N/N=C(CC)\C2=CC=C(C(C)=C2O)O
Molecular Formula
C19H23N3O3
Molecular Weight
341.40
References & Citations
[1]Cardiomyocyte growth promoter. JP2023007595A 2023-01-19.|[2]Aihara A, et al. Small molecule LATS kinase inhibitors block the Hippo signaling pathway and promote cell growth under 3D culture conditions. J Biol Chem. 2022 Apr;298 (4) :101779.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Cardiomyocyte proliferation promoting agent-1
CAS Number2351906-71-1
PubChem CID146736742
IUPAC Name2-anilino-N-[(Z)-1-(2,4-dihydroxy-3-methylphenyl)propylideneamino]propanamide
Molecular FormulaC19H23N3O3
Molecular Weight341.4
XLogP3.6
Topological Polar Surface Area94
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count25
Formal Charge0
Complexity463
SMILES
CC/C(=N/NC(=O)C(C)NC1=CC=CC=C1)/C2=C(C(=C(C=C2)O)C)O
InChI
InChI=1S/C19H23N3O3/c1-4-16(15-10-11-17(23)12(2)18(15)24)21-22-19(25)13(3)20-14-8-6-5-7-9-14/h5-11,13,20,23-24H,4H2,1-3H3,(H,22,25)/b21-16-
InChIKey
RJHQUBJDRHLKEX-PGMHBOJBSA-N
Chemical Structure
2D Structure
2D structure of Cardiomyocyte proliferation promoting agent-1
CAS: 2351906-71-1
CID: 146736742
Formula: C19H23N3O3
MW: 341.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight341.4
XLogP33.6
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass341.17394160
Monoisotopic Mass341.17394160
Topological Polar Surface Area94 Ų
Heavy Atom Count25
Formal Charge0
Complexity463
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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