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MIDD0301 (sodium)

CAT: 0804-HY-123801ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123801ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MIDD0301 (GL-II-93) is an orally available, active γ-aminobutyric acid type A receptor (GABAAR) inhibitor and anti-asthmatic agent. MIDD0301 exhibits biological and immunotoxicological safety in mice and does not affect the number of circulating lymphocytes, monocytes, and granulocytes. MIDD0301 has no significant adverse immune response at repeated doses, which is better than Prednisone. MIDD0301 relaxes histamine-contracted guinea pig and human airway smooth muscle and is used in the study of bronchoconstrictive diseases[1][2].
CAS Number
2593569-36-7
Product Name Alternative
GL-II-93 (sodium)
UNSPSC
12352101
Target
GABA Receptor
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=C2N(C=N1)C3=CC=C(Br)C=C3C(C4=C(C=CC=C4)F)=N[C@@H]2C)O[Na]
Molecular Formula
C19H12BrFN3NaO2
Molecular Weight
436.21
References & Citations
[1]Zahn NM, et al. MIDD0301 - A first-in-class anti-inflammatory asthma drug targets GABAA receptors without causing systemic immune suppression. Basic Clin Pharmacol Toxicol. 2019 Jul;125 (1) :75-84.|[2]Yocum GT, et al. A novel GABAA receptor ligand MIDD0301 with limited blood-brain barrier penetration relaxes airway smooth muscle ex vivo and in vivo. Am J Physiol Lung Cell Mol Physiol. 2019 Feb 1;316 (2) :L385-L390.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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