Nivocasan

• Description:

  Nivocasan (GS 9450; LB-84451) is a pan-caspase inhibitor that irreversibly arrests caspase-1 activity and inhibits that of caspase-8. Nivocasan inhibits IL-1β cleavage and blocks osteoclast differentiation. Nivocasan inhibits the protein expression of NFATc1 and CSTK[1].

• Product Name Alternative:

  GS 9450; LB-84451

• UNSPSC:

  12352005

• Target:

  Caspase; Interleukin Related

• Related Pathways:

  Apoptosis; Immunology/Inflammation

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  FC[C@@](O)(OC(C1)=O)[C@H]1NC([C@@]2(CC(C3=NC=CC4=C3C=CC=C4)=NO2)C(C)C)=O

• Molecular Formula:

  C21H22FN3O5

• Molecular Weight:

  415.41

• References & Citations:

  [1]Kim HY, et al. Auranofin Inhibits RANKL-Induced Osteoclastogenesis by Suppressing Inhibitors of κB Kinase and Inflammasome-Mediated Interleukin-1β Secretion. Oxid Med Cell Longev. 2019 Apr 22;2019:3503912.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  Caspase 1; Caspase 8; IL-1

• CAS Number:

  [908253-63-4]