AAA

• Description :

  AAA is a potent blocker of 20-Hydroxyeicosatetraenoic acid (20-HETE) receptor that binds directly to GPR75 and prevents the increases in intracellular Ca2+, IP-1 and β-arrestin[1].

• UNSPSC :

  12352211

• Target :

  Orphan GPCR; Orphan Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/aaa.html

• Purity :

  99

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@@H](NC(CCCC/C=C\CCCCCCC/C=C\CCCCO)=O)CC(O[Na])=O)O[Na]

• Molecular Formula :

  C24H39NNa2O6

• Molecular Weight :

  483.55

• References & Citations :

  [1]Jonathan V. Pascale, et al. 20-Hydroxyeicosatetraenoic acid (20-HETE) : Bioactions, receptors, vascular function, cardiometabolic disease and beyond. Adv Pharmacol. 2023; 97: 229–255.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 4