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(R) -Glutor

CAT: 0804-HY-158302A-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-158302A-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -Glutor is the R-enantiomer of Glutor. Glutor is a selective GLUT 1/2/3 inhibitor that can suppress glucose uptake. Glutor can inhibit glycolysis and has anti-tumor activity, inducing cell apoptosis[1][2].
CAS Number
2674750-95-7
UNSPSC
12352005
Target
Apoptosis; GLUT
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Field of Research
Cancer
Purity
99.61
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@]1(C)N(C(C2=CC(C3=CC=CC=C3)=NN2C1)=O)CC(C=C4)=CC=C4N5CCOCC5)NCC6=CC=CN=C6
Molecular Formula
C31H32N6O3
Molecular Weight
536.62
References & Citations
[1]Reckzeh ES, et al. Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth. Cell Chem Biol. 2019;26 (9) :1214-1228.e25.|[2]Mithlesh Kumar Temre, et al. Glutor, a Glucose Transporter Inhibitor, Exerts Antineoplastic Action on Tumor Cells of Thymic Origin: Implication of Modulated Metabolism, Survival, Oxidative Stress, Mitochondrial Membrane Potential, pH Homeostasis, and Chemosensitivity. Front Oncol. 2022 Jun 30:12:925666.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(R)-Glutor
CAS Number2674750-95-7
PubChem CID177674989
IUPAC Name(6R)-6-methyl-5-[(4-morpholin-4-ylphenyl)methyl]-4-oxo-2-phenyl-N-(pyridin-3-ylmethyl)-7H-pyrazolo[1,5-a]pyrazine-6-carboxamide
Molecular FormulaC31H32N6O3
Molecular Weight536.6
XLogP2.6
Topological Polar Surface Area92.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count40
Formal Charge0
Complexity869
SMILES
C[C@@]1(CN2C(=CC(=N2)C3=CC=CC=C3)C(=O)N1CC4=CC=C(C=C4)N5CCOCC5)C(=O)NCC6=CN=CC=C6
InChI
InChI=1S/C31H32N6O3/c1-31(30(39)33-20-24-6-5-13-32-19-24)22-37-28(18-27(34-37)25-7-3-2-4-8-25)29(38)36(31)21-23-9-11-26(12-10-23)35-14-16-40-17-15-35/h2-13,18-19H,14-17,20-22H2,1H3,(H,33,39)/t31-/m1/s1
InChIKey
RJNNHMLTCJHHRQ-WJOKGBTCSA-N
Chemical Structure
2D Structure
2D structure of (R)-Glutor
CAS: 2674750-95-7
CID: 177674989
Formula: C31H32N6O3
MW: 536.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight536.6
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass536.25358890
Monoisotopic Mass536.25358890
Topological Polar Surface Area92.6 Ų
Heavy Atom Count40
Formal Charge0
Complexity869
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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TYD-02900-01(R) -Glutor

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