Idasanutlin (Standard)

CAT: 0804-HY-15676R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15676R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Idasanutlin (Standard) is the analytical standard of Idasanutlin. This product is intended for research and analytical applications. Idasanutlin (RG7388) is a potent and selective MDM2 antagonist, inhibiting p53-MDM2 binding, with an IC50 of 6 nM.
CAS Number
[1229705-06-9]
UNSPSC
12352100
Target
E1/E2/E3 Enzyme; MDM-2/p53; Reference Standards
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C(O)C1=CC(OC)=C(NC([C@H]2[C@H](C3=C(F)C(Cl)=CC=C3)[C@](C4=CC=C(Cl)C=C4F)(C#N)[C@H](CC(C)(C)C)N2)=O)C=C1
Molecular Formula
C31H29Cl2F2N3O4
Molecular Weight
616.48
References & Citations
[1]Ding Q, et al. Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development. J Med Chem. 2013 Jul 25;56 (14) :5979-83.|[2]Higgins B, et al. Preclinical optimization of MDM2 antagonist scheduling for cancer treatment by using a model-based approach. Clin Cancer Res. 2014, 20 (14), 3742-3752.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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