Idasanutlin

• Description :

  Idasanutlin (RG7388) is a potent and selective MDM2 antagonist, inhibiting p53-MDM2 binding, with an IC50 of 6 nM.

• CAS Number :

  [1229705-06-9]

• Product Name Alternative :

  RG7388

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  E1/E2/E3 Enzyme; MDM-2/p53

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/RG7388.html

• Purity :

  99.93

• Solubility :

  DMSO : ≥ 45 mg/mL

• Smiles :

  O=C(O)C1=CC(OC)=C(NC([C@H]2[C@H](C3=C(F)C(Cl)=CC=C3)[C@](C4=CC=C(Cl)C=C4F)(C#N)[C@H](CC(C)(C)C)N2)=O)C=C1

• Molecular Formula :

  C31H29Cl2F2N3O4

• Molecular Weight :

  616.48

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Ding Q, et al. Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development. J Med Chem. 2013 Jul 25;56 (14) :5979-83.|[2]Higgins B, et al. Preclinical optimization of MDM2 antagonist scheduling for cancer treatment by using a model-based approach. Clin Cancer Res. 2014, 20 (14), 3742-3752.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3