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APD668 (Standard)

CAT: 0804-HY-15565R-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15565R-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APD668 (Standard) is the analytical standard of APD668. This product is intended for research and analytical applications. APD668 is a potent, selective and orally active agonist of G-protein coupled receptor GPR119, with EC50s of 2.7 nM and 33 nM for hGPR119 and rGPR119, respectively. APD668 shows no significant inhibition of any of the five major CYP isoforms with the exception of CYP2C9 (Ki=0.1 μM) . APD668 can be used for the research of steatohepatitis and diabetes[1][2].
CAS Number
832714-46-2
UNSPSC
12352100
Target
Cytochrome P450; GPR119; Potassium Channel; Reference Standards
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Metabolic Disease
Smiles
O=C(OC(C)C)N(CC1)CCC1OC2=C3C(N(C4=CC=C(S(=O)(C)=O)C=C4F)N=C3)=NC=N2
Molecular Formula
C21H24FN5O5S
Molecular Weight
477.51
References & Citations
[1]Semple G, et al. Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. Bioorg Med Chem Lett. 2011 May 15;21 (10) :3134-41.|[2]Bahirat UA, et, al. APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice. Eur J Pharmacol. 2017 Apr 15;801:35-45.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

CatalogName
B4671-5.1APD668
A14342-25APD668 25mg
A14342-10APD668 10mg
A14342-100APD668 100mg
A14342-5APD668 5mg
A14342-1APD668 1mg
A14342-50APD668 50mg
A14342-10mM-DAPD668 10mM * 1mL in DMSO
abx098967-01Standard

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