Products for Research Use Only
RegisterLogin

APD668

CAT: 0804-HY-15565-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-15565-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
APD668 is a potent, selective and orally active agonist of G-protein coupled receptor GPR119, with EC50s of 2.7 nM and 33 nM for hGPR119 and rGPR119, respectively. APD668 shows no significant inhibition of any of the five major CYP isoforms with the exception of CYP2C9 (Ki=0.1 μM) . APD668 can be used for the research of steatohepatitis and diabetes[1][2].
CAS Number
832714-46-2
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Cytochrome P450; GPR119; Potassium Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/APD668.html
Purity
99.73
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(OC(C)C)N(CC1)CCC1OC2=C3C(N(C4=CC=C(S(=O)(C)=O)C=C4F)N=C3)=NC=N2
Molecular Formula
C21H24FN5O5S
Molecular Weight
477.51
Precautions
H315, H319, H335
References & Citations
[1]Semple G, et al. Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. Bioorg Med Chem Lett. 2011 May 15;21 (10) :3134-41.|[2]Bahirat UA, et, al. APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice. Eur J Pharmacol. 2017 Apr 15;801:35-45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
CYP2

Alternative Products

CatalogName
B4671-5.1APD668
A14342-25APD668 25mg
A14342-10APD668 10mg
A14342-5APD668 5mg
A14342-1APD668 1mg
A14342-100APD668 100mg
A14342-50APD668 50mg
A14342-10mM-DAPD668 10mM * 1mL in DMSO

Popular Products