LD4172

CAT: 0804-HY-153598-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-153598-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

LD4172 is a PROTAC degrader for RIP kinase (RIPK1) with DC50 in nanomolare levels. LD4172 induces apoptosis in cell B16F10 with combination of TNF-α. LD4172 exhibits antitumor efficacy in mouse models[1]. (Pink: ligand for target protein ; Black: linker (HY-W012241) ; Blue: ligand for E3 ligase VHL (HY-112078) )

CAS Number

2782022-40-4

UNSPSC

12352005

Target

PROTACs; RIP kinase

Related Pathways

Apoptosis; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

98.32

Solubility

DMSO : 100 mg/mL

Smiles

O=C(CC1=CC=CC(OC(F)(F)F)=C1)N2CCC3=C2C=CC(C4=CN(C5=NC=NC(N)=C45)CCCNC(CCCCCCCCCCC(N[C@H](C(N6C[C@@H](C[C@H]6C(N[C@H](C7=CC=C(C=C7)C8=C(N=CS8)C)C)=O)O)=O)C(C)(C)C)=O)=O)=C3

Molecular Formula

C61H75F3N10O7S

Molecular Weight

1149.37

References & Citations

[1]Yu X, et al., Development of a RIPK1 degrader to enhance antitumor immunity. Nat Commun. 2024 Dec 16;15 (1) :10683.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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