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LD4172

CAT: 0931-T204416-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204416-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2782022-40-4
Target
RIP kinase, PROTACs
Related Pathways
NF-κB, PROTAC, Apoptosis
Bioactivity
LD4172 is a PROTAC degrader capable of degrading RIP kinase (RIPK1) with a DC50 in the nanomolar range. When used in combination with TNF-α, LD4172 can induce apoptosis in B16F10 cells. In mouse models, it demonstrates antitumor activity. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL)
Smiles
NC1=C2C(=CN(CCCNC(CCCCCCCCCCC(N[C@H](C(=O)N3[C@H](C(N[C@@H](C)C4=CC=C(C=C4)C=5SC=NC5C)=O)C[C@@H](O)C3)[C@](C)(C)C)=O)=O)C2=NC=N1)C=6C=C7C(=CC6)N(C(CC8=CC(OC(F)(F)F)=CC=C8)=O)CC7
Molecular Formula
C61H75F3N10O7S
Molecular Weight
1149.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
GTR19250252-01LD4172

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