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Δ2-Avermectin B1a

CAT: 0804-HY-15308BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-15308BSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Δ²-Avermectin B₁ₐ (Compound 3) is an antiparasitic agent targeting glutamate-gated chloride channels (GluCls) in the neuromuscular system of invertebrates. Δ²-Avermectin B₁ₐ enhances chloride ion influx, leading to hyperpolarization of the neuromuscular cell membrane, inhibition of neural signal transmission, and ultimately paralysis and death of parasites. Δ²-Avermectin B₁ₐ is promising for research of agricultural pests[1].
CAS Number
110415-68-4
UNSPSC
12352005
Target
Chloride Channel; Parasite
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Smiles
C/C([C@H]([C@H](/C=C/C=C1[C@]2(C3=C[C@@H]([C@H]([C@]2(OC/1)[H])O)C)O)C)O[C@]4(C[C@@H]([C@H]([C@@H](O4)C)O[C@@]5(O[C@H]([C@@H]([C@H](C5)OC)O)C)[H])OC)[H])=C\C[C@@]6(C[C@@]([H])(C[C@@]7(O6)C=C[C@@H]([C@]([H])(O7)[C@H](CC)C)C)OC3=O)[H]
Molecular Formula
C48H72O14
Molecular Weight
873.08
References & Citations
[1]Pivnichny J V, et al. Base-catalyzed isomerization of avermectins[J]. Journal of agricultural and food chemistry, 1988, 36 (4) : 826-828.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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