Products for Research Use Only
RegisterLogin

EMD638683

CAT: 0804-HY-15193-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-15193-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
EMD638683 is a highly selective SGK1 inhibitor, with an IC50 value of 3 μM.
CAS Number
1181770-72-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
SGK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/EMD638683.html
Purity
99.94
Solubility
DMSO : ≥ 50 mg/mL
Smiles
CC1=C(CC)C(C(NNC(C(O)C2=CC(F)=CC(F)=C2)=O)=O)=CC=C1O
Molecular Formula
C18H18F2N2O4
Molecular Weight
364.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Ackermann TF, et al. EMD638683, a novel SGK inhibitor with antihypertensive potency. Cell Physiol Biochem. 2011;28 (1) :137-46.|[2]Towhid ST, et al. Inhibition of colonic tumor growth by the selective SGK inhibitor EMD638683. Cell Physiol Biochem. 2013;32 (4) :838-48.|[3]Xi X, et al. Serum-glucocorticoid regulated kinase 1 regulates macrophage recruitment and activation contributing to monocrotaline-induced pulmonary arterial hypertension. Cardiovasc Toxicol. 2014 Dec;14 (4) :368-78.|[4]Zhou H, et al. Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure. FASEB J. 2015 Sep;29 (9) :3737-49.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SGK1

Alternative Products

CatalogName
BUP02999-01EMD638683
A15079-100EMD638683 100mg
A15079-25EMD638683 25mg
A15079-50EMD638683 50mg
A15079-5EMD638683 5mg
A15079-10EMD638683 10mg
A15079-1EMD638683 1mg
MBS386751-01EMD638683 S-Form

Popular Products