MRS4719-d3

CAT: 0804-HY-151547SSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-151547SSize:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MRS4719-d3 is the deuterium labeled MRS4719 (HY-151547) . MRS4719 is a potent P2X4 receptor antagonist with an IC50 value of 0.503 μM for human P2X4 receptor. MRS4719 can reduce infarct volume and reduce brain atrophy, showing neuroprotective and neuro-rehabilitative activities in ischemic stroke model. MRS4719 also reduces ATP-induced [Ca2+]i influx in primary human monocyte-derived macrophages. MRS4719 can be used to research ischemic stroke[1].
UNSPSC
12352005
Target
Isotope-Labeled Compounds; P2X Receptor
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Neurological Disease
Smiles
CC[NH+](CC)CC.O=C(NC1=C2C=CC=CC2=CC=C1N3C4=C([2H])C(C([N-]5)=NOC5=S)=NC([2H])=C4[2H])CC3=O
Molecular Formula
C26H25D3N6O3S
Molecular Weight
507.62
References & Citations
[1]Toti KS, et al. Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2H-naphtho[1,2-b][1,4]diazepine-2,4 (3H) -diones as P2X4 Receptor Antagonists. J Med Chem. 2022 Sep 23.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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