Bemcentinib-d8

CAT: 0804-HY-15150SSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-15150SSize:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bemcentinib-d8 (R428-d8) is the deuterium labeled Bemcentinib (HY-15150) . Bemcentinib (R428) is a selective and orally active Axl inhibitor with an IC50 of 14 nM. Bemcentinib retards cancer cell migration and invasion. Bemcentinib exhibits >100-fold selectivity for Axl versus Abl and 50- and >100-fold selectivity over TAM family kinases Mer and Tyro3, respectively, in cells. Bemcentinib blocks tumor spread and prolongs survival in models of metastatic breast cancer[1][2].
Product Name Alternative
R428-d8; BGB324-d8
UNSPSC
12352005
Target
Isotope-Labeled Compounds; TAM Receptor
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
NC1=NC(NC2=CC(CC[C@@H](N3C([2H])([2H])C([2H])([2H])C([2H])([2H])C3([2H])[2H])CC4)=C4C=C2)=NN1C(N=N5)=CC6=C5C7=CC=CC=C7CCC6
Molecular Formula
C30H26D8N8
Molecular Weight
514.69
References & Citations
[1]Sensi M, et al. Human cutaneous melanomas lacking MITF and melanocyte differentiation antigens express a functional Axl receptor kinase. J Invest Dermatol. 2011 Dec;131 (12) :2448-57. |[2]Holland SJ, et al. R428, a selective small molecule inhibitor of Axl kinase, blocks tumor spread and prolongs survival in models of metastatic breast cancer. Cancer Res. 2010 Feb 15;70 (4) :1544-54.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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