Products for Research Use Only
RegisterLogin

Romidepsin (GMP)

CAT: 0804-HY-15149GSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-15149GSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Romidepsin (GMP) (FK 228 (GMP) ) is Romidepsin produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Romidepsin (FK 228) is a Histone deacetylase (HDAC) inhibitor with anti-tumor activities. Romidepsin (FK 228) inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1.4 μM, respectively[1]. Romidepsin (FK 228) is produced by Chromobacterium violaceum, induces cell G2/M phase arrest and apoptosis[2].
Product Name Alternative
FK 228 (GMP) ; FR 901228 (GMP) ; NSC 630176 (GMP)
UNSPSC
12352005
Target
Apoptosis; HDAC
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
C/C=C(NC([C@@H](CSSCC/C=C/[C@@H](O1)CC2=O)NC([C@@H](C(C)C)N2)=O)=O)/C(N[C@@H](C(C)C)C1=O)=O
Molecular Formula
C24H36N4O6S2
Molecular Weight
540.70
References & Citations
[1]Furumai R, et al. FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res. 2002 Sep 1;62 (17) :4916-21.|[2]Sun WJ, et al. Romidepsin induces G2/M phase arrest via Erk/cdc25C/cdc2/cyclinB pathway and apoptosis induction through JNK/c-Jun/caspase3 pathway in hepatocellular carcinoma cells. Biochem Pharmacol. 2017 Mar 1;127:90-100.
Shipping Conditions
Room temperature
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported

Related Products

CatalogName
HY-15149-01Romidepsin
HY-15149S2Romidepsin-d7
HY-10219G-01Rapamycin (GMP)
HY-N0737AG-01Harmine (GMP)
HY-N0083GBetulin (GMP)
HY-15682G-01TTNPB (GMP)
HY-15794GNemorubicin (GMP)
HY-B1505GAcefylline (GMP)
HY-13506G-01M344 (GMP)
HY-107632GGYY4137 (GMP)

Alternative Products

CatalogName
FR10656-01Romidepsin
MBS516378-01Romidepsin (FK228)
CS-T-96294Romidepsin-d8

Popular Products