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(R) -STU104-d6

CAT: 0804-HY-150612S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-150612S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(R) -STU104-d6 is a deuterium labeled (R) -STU104. (R) -STU104 is a potent and orally active TAK1-MKK3 interaction inhibitor with IC50s of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation. (R) -STU104 suppresses the TAK1/MKK3/p38/MnK1/MK2/elF4E signal pathways through binding with MKK3 and disrupting the TAK1 phosphorylating MKK3. (R) -STU104 can be used for researching ulcerative colitis[1].
CAS Number
3063042-81-6
UNSPSC
12352005
Target
Isotope-Labeled Compounds; p38 MAPK
Related Pathways
MAPK/ERK Pathway; Others
Field of Research
Cancer
Purity
99.90
Smiles
O=C1C2=CC(OC([2H])([2H])[2H])=CC(OC([2H])([2H])[2H])=C2[C@@H](C3=CC=C(OC)C=C3)C1
Molecular Formula
C18H12D6O4
Molecular Weight
304.37
References & Citations
[1]Tang ML, et al. Discovery of First-in-Class TAK1-MKK3 Protein-Protein Interaction (PPI) Inhibitor (R) -STU104 for the Treatment of Ulcerative Colitis through Modulating TNF-α Production. J Med Chem. 2022 May 12;65 (9) :6690-6709.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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