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(R) -STU104-d6

CAT: 0931-T207425-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T207425-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3063042-81-6
Target
P38 MAPK
Related Pathways
MAPK
Bioactivity
(R) -STU104-d6 is a deuterium-labeled variant of (R) -STU104. This compound acts as a potent and orally active inhibitor of the interaction between TAK1 and MKK3 proteins, exhibiting IC50 values of 0.58 μM for TNF-α and 4.0 μM for MKK3 phosphorylation. By binding to MKK3, (R) -STU104 hinders TAK1's ability to phosphorylate MKK3, thereby disrupting the TAK1/MKK3/p38/MnK1/MK2/elF4E signaling pathway. It is utilized in research related to ulcerative colitis.
Smiles
O(C([2H])([2H])[2H])C1=C2[C@H](CC(=O)C2=CC(OC([2H])([2H])[2H])=C1)C3=CC=C(OC)C=C3
Molecular Formula
C18H182D6O4
Molecular Weight
304.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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