IMA-1

• Description :

  IMA-1 is an inhibitor that inhibits the interaction between arachidonic acid 12-lipoxygenase (ALOX12) and acetyl-CoA carboxylase 1 (ACC1) . IMA-1 significantly blocks the progression of diet-induced non-alcoholic steatohepatitis (NASH) in male mice and crab-eating monkeys, and does not cause hyperlipidemia. IMA-1 can be used for the study of NASH[1].

• UNSPSC :

  12352005

• Target :

  Acetyl-CoA Carboxylase; Lipoxygenase

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Metabolic Disease

• Smiles :

  O=S(C(C=C1)=CC=C1NCC(C=CC=C2OC)=C2O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O)(NC4=NC5=CC=CC=C5S4)=O

• Molecular Formula :

  C27H27N3O10S2

• Molecular Weight :

  617.65

• References & Citations :

  [1]Zhang XJ, et al. A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques. Sci Transl Med. 2021 Dec 15;13 (624) :eabg8116.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [2315406-63-2]