PBF-999

• Description:

  PBF-999 is a phosphodiesterase10A (PDE-10A) and adenosine A2A receptor (A2AR) dual antagonist. PBF-999 binds to and inhibits the activity of PDE-10A, thereby preventing the degradation of cGMP. PBF-999 can be used for the study of solid tumour advanced cancer[1].

• UNSPSC:

  12352005

• Target:

  Adenosine Receptor; Phosphodiesterase (PDE)

• Related Pathways:

  GPCR/G Protein; Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Smiles:

  BrC1=C(NCC#C)N=C(N2N=CN=C2)N=C1N

• Molecular Formula:

  C9H8BrN7

• Molecular Weight:

  294.11

• References & Citations:

  [1]Yu F, et al. Adenosine A2A Receptor Antagonists for Cancer Immunotherapy. J Med Chem. 2020 Nov 12;63 (21) :12196-12212.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  Adenosine A2A receptor (A2AR) ; PDE10

• CAS Number:

  [1620909-95-6]