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Rel-Avibactam (sodium)

CAT: 0804-HY-14879ESize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14879ESize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ent-Avibactam (NXL-104) sodium is a β-lactamase inhibitor with broad-spectrum antibacterial activity. When combined with Cefazidime , rel-Avibactam sodium exhibits significant inhibitory effects on Enterobacteriaceae bacteria that produce Ambler A and C types of β-lactamases. The IC50 value of rel-Avibactam sodium is much lower than that of commonly used β-lactamase inhibitors Clavulanic acid (HY-A0256) and Ticarcillin (HY-139805), demonstrating its high efficiency in inhibiting TEM-1 and P99 enzymes[1][2].
CAS Number
1383814-68-3
Product Name Alternative
NXL-104 (sodium)
UNSPSC
12352005
Target
Bacterial; Beta-lactamase
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
NC([C@@H]1[N@]2C(N([C@](CC1)([H])C2)OS(=O)(O[Na])=O)=O)=O
Molecular Formula
C7H10N3NaO6S
Molecular Weight
287.23
References & Citations
[1]Meiji Seika, et al. Preparation of optically-active diazabicyclooctane derivative and method for manufacturing same. WO2012086241.|[2]In vitro activity of AVE1330A, an innovative broad-spectrum non-beta-lactam beta-lactamase inhibitor
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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