Avibactam (sodium hydrate)

• UNSPSC Description:

  Avibactam sodium (NXL-104) hydrate is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].

• Target Antigen:

  Antibiotic; Bacterial; Beta-lactamase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Avibactam-sodium-hydrate.html

• Solubility:

  H2O : ≥ 200 mg/mL

• Smiles:

  O=S(ON1[C@]2([H])CC[C@@H](C(N)=O)[N@@](C2)C1=O)(O[Na])=O.O

• Molecular Weight:

  305.24

• References & Citations:

  [1]Ehmann DE, et al. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8.|[2]Livermore DM, et al. Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104). J Antimicrob Chemother. 2012 Jun;67(6):1354-8.|[3]Berkhout J, et al. Pharmacokinetics and penetration of GR20263 and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrob Agents Chemother. 2015 Apr;59(4):2299-304.|[4]Zhang W, et al. In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing Klebsiella pneumoniae. Antimicrob Resist Infect Control. 2018 Nov 21;7:142.Int J Infect Dis. 2021 Apr 14;S1201-9712(21)00346-5.|J Clin Microbiol. 2020 Aug 24;58(9):e00932-20.|ACS Infect Dis. 2021 Jun 30.|Acta Microbiol Immunol Hung. 2021 Jul 29.|Adv Ther (Weinh). 2024 Jan 12.|Antibiotics (Basel). 2021 Sep 14;10(9):1110.|Antibiotics (Basel). 2021, 10(11), 1341.|Antibiotics (Basel). 2022, 11(10), 1280.|Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00414-18. |Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00433-18.|Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00282-18. |Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00873-18.|Antimicrob Agents Chemother. 2022 Jun 1;e0240221.|Antimicrob Agents Chemother. 2023 Jan 23;e0145922.|bioRxiv. 2021 Mar 13.|bioRxiv. 2024 Sep 25:2024.09.25.615047.|Biosens Bioelectron. 2021 Jul 21;193:113526.|Cell Rep. 2024 Nov 9;43(11):114962.|Infect Drug Resist. 2020 Aug 18;13:2883-2890.|Infect Drug Resist. 2021 Jun 30;14:2499-2507.|Int J Antimicrob Agents. 2018 Aug;52(2):269-271.|Int J Antimicrob Agents. 2024 Jun 24:107256.|Int J Antimicrob Agents. 2024 May 14:107206.|Int J Infect Dis. 2020 Apr;93:252-257. |Int J Med Microbiol. 2021 Oct;70(10).|Int J Mol Sci. 2021, 22(6), 3051.|J Antimicrob Chemother. 2021 Feb 11;76(3):653-658.|J Antimicrob Chemother. 2021 May 6;dkab141.|J Antimicrob Chemother. 2022 Jul 15;dkac232.|J Antimicrob Chemother. 2023 Feb 13;dkad032.|J Infect Dev Ctries. 2021 Mar 31;15(3):404-414.|J Infect Dis. 2019 Jul 2;220(3):484-493. |Microbiol Spectr. 2022 Aug 16;e0139022.|Microbiol Spectr. 2022 Aug 24;e0203522.|Microbiol Spectr. 2022 Dec 8;e0303822.|Microbiol Spectr. 2023 Nov 20:e0304723.|Microbiol Spectr. 2024 Sep 3.|Nature. 2024 Aug;632(8026):893-902.|Open Forum Infect Dis. 2024 Oct 11;11(11):ofae611.|RSC Adv. 2023 Nov 30;13(49):34884-34890.|Sci Rep. 2022 Oct 7;12(1):16814.|Antibiotics (Basel). 2023 Jul 20, 12(7), 1212.|Antibiotics (Basel). 2024 May 1, 13(5), 416.|Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02260-16.|Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01809-18.|Antimicrob Agents Chemother. 2019 Aug 23;63(9):e01374-19.|Antimicrob Agents Chemother. 2019 Sep 16;63(12):e01515-19.|Antimicrob Agents Chemother. 2020 Feb 21;64(3):e02025-19.|Antimicrob Agents Chemother. 2020 Sep 21;64(10):e00409-20.|Antimicrob Agents Chemother. 2023 May 18;e0160322.|Antimicrob Agents Chemother. 2023 May 31;e0033923.|Antimicrob Agents Chemother. 2023 Sep 6;e0052823.|Antimicrob Agents Chemother. 2023 Sep 8;e0030123.|Antimicrob Agents Chemother. 2024 Oct 4:e0077524.|Biomed Res Int. 2018 Jul 2;2018:3579832. |BMC Microbiol. 2020 Jun 29;20(1):187.|BMC Microbiol. 2019 Nov 1;19(1):240.|Eur J Clin Microbiol Infect Dis. 2024 Nov 26.|Int J Med Microbiol. 2020 Jul;69(7):928-931.|J Antimicrob Chemother. 2017 Jul 1;72(7):1930-1936.|J Antimicrob Chemother. 2017 Sep 1;72(9):2483-2488.|J Antimicrob Chemother. 2020 Sep 1;75(9):2609-2615.|J Antimicrob Chemother. 2024 Apr 2:dkae097.|J Clin Microbiol. 2023 Apr 18;e0164722.|Microb Drug Resist. 2020 Apr;26(4):334-340.|Microbiol Spectr. 2023 Apr 24;e0069223.|Preprints. 2023 Jun 21.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Launched

• CAS Number:

  2938989-90-1